A friend of a friend asked me about what treatment did I use for for Babesia  because his Doctor gave him one week of Mepron and refuses to treat him longer; the friend of my friend thinks one week of treatment is not enough and is searching to get other possible treatments.   This is my answer:
“I guess E. told you to contact me because we have spoken before about ways to treat the parasites.  As you might know  Babesia is a big parasite that travels inside the red blood cells, imagine that, a bug living out of our life resource, so of course the anemia is huge and the symptoms are many. I found Babesia to be worse than malaria because the parasites of the malaria go inside the red blood cell but one at a time, the Babesia seems to be a gringo malaria smarter and stronger because two and sometimes three bugs go inside each red blood cell; "Babesia bigemina"? Means two! This is not to scare you but to show why it is indeed vital to treat it and as long as it is needed.
I am Hispanic, so I always heard about treating parasites in my home country, and then I traveled and lived in an area that was endemic of malaria, so this topic is not  new to me, what surprises me is to find it here in the US where in theory there are "no parasites" in the US,  and of course no infections of this type like in South America or Africa.  
So in my case living in Florida, after many Doctors and tons of not knowing what was wrong with me and after lots of suffering and finally treating with antibiotics for long time and not recovering I called my former family physician in Colombia and he remembered me and helped me by phone and all I am going to tell you and what I write in my blog is based on his teaching and my researching meaning, I am not an expert, nor the wise one here, just a friend willing to share and help if I can; at least I try.
The one thing about your case that calls my attention and I have seen here a lot is,  why Drs do not re-test?  Your Doc treated you, thank you, but he won't re-test to see if his treatment worked?  Who he thinks he is?  God? Or his treatment is the ultimate cure? Really?

To the point - finally sorry -
I have been taking Ivermectin - this is an anthelmintic, meaning anti-parasitic.  There are many medicines of this type, Flagyl, Tindamax and even herbs and garlic are part of the group (see in the bottom from Wikipedia the definition and types of anthelmintics).  The difference with Ivermectin is that this drug started as a veterinarian medicine - and if you permit me my opinion, medicines made for animals are made to cure them; the ones for us are made to keep us going to the Dr and taking more medicines to fill their pockets.
Seriously, it was a veterinary medicine and then used in humans and after twenty years or more using it in South America and in Africa the US is starting to use it.  In most parts it is used as antiparasitic and in Africa not only as anti-malarial but also to treat "filarial infections" such as "Onchoneriasis" or also called "River blindness".  As long as I've heard Mr. Burgdorferi said the ticks transmit a bacterium called Borrelia and also some protozoans of the filarial type; of course the medical community doesn't want to hear this and are consciously ignoring the filarial infection condemning the patients to not be cured!
For all this the Ivermectin seems to be the medicine to treat us, both filarial infections and Babesia.  But that is not all.  My Dr told me that Ivermectin was found to not hurt the Central Nervous system as many of the anthelmintics do; plus, he didn't want me to take regular antimalarials because those act by immune suppression and me, we, Lymies have multiple infections bacterial and parasitic that could be free of growing if there is immune suppression.  So again my Dr recommended me to take Ivermectin to begin with.  He said that if I needed to combine it, or to altern it from time time time I could take Alinia was his second drug of choice, again because it seems to not hurt the Central Nervous system as much.  In my country Albendazole is very used to treat malaria and parasites, but he preferred me to not take it if I could have Ivermectin instead or Alinia -Nitaxozanida. The "Albenda" as many call it her in the US was found to hurt the CNS to the point children were showing symptoms similar to Parkinson's. But a short treatment is good, not the long one intended for me.
So how to take the Ivermectin?  after seeing my labs my Dr said I had so many infections running at the same time and so many of them being parasitic, I must start very low in the treatment and do it for long time.  He said the strong treatments are better for the acute infections and when the patient is not that invaded yet.  By "invaded" I mean the parasites can lay from 250 to 250,000 eggs even per day, week or month, so the more they reproduce and travel around the body the sicker we are - invaded I mean! My Dr said the toxins the parasite release are the ones that make us sicker even more than having he parasite eating us alive, these toxins are released in bigger amounts when the bugs die (their poop in clear words); also the medicine itself to be able to kill parasites is a big toxin (now we are talking about two time toxicity when killing parasites), and the last third big toxin load we get is the bodies of the dead parasites, imagine these creatures dead and our body trying to get rid of them.  We need good bacteria to come eat these dead bodies –debris-, and we need to eat papaya and good digestive enzymes to help the belly and digestive process and then we need to detox with treatments like enemas and colonics to kick them out. Also Castor oil and Milk of magnesia help a lot!
Yes my first treatment was truly strong, I thought I was stronger than those bugs and I could kill them before they could kill me so i took a higher dose..  Of course I was wrong, lol, got so sick that I had to call my Doc and he almost yell at me: cut the dose in half and keep it long time, 3 to six months before considering to raise it to your regular dose; and that I did. I've been taking it once a week long time!
Which is the dose?  the Ivermectin sold in SA is a little bottle like tear drops and the dose is one drop per one kilogram ONCE A WEEK in my case due to my overload; meaning it is a dose according to each one's weight and condition, and it is not given daily due to the medicine stays in the body four days.  So if I was supposed to take 50 drops I started with 25 and just around the first year I was taking the dose for me.  I kept my antibiotics until I was able to not take them anymore, and I do probiotics and eat papaya every day and try to take some care eating without sugar nor carbs.
After all my meds from my home country were finished I looked for options here in the US.  I found the Ivermectin here is called "Stromectol" comes in pills, boxes of 3 or 6 pills and it is very expensive.  I guess these pills must be of a lesser concentration than my liquid human version because I found some Drs here, well Dr K who comes from outside of the US, gives 12 mgs a day and sometimes he gives 12 mgs three times a day for two weeks and to some patients he has given them this "megadose" every day for one month? I called my Dr and asked for his opinion.  He was the one that concluded that probably the pills were less concentrated and could be given in such amounts.  The dose I've taken is barely 3 mgs once a week, and I have not had any bad reaction and I can talk about recovering.  So Stromectol is one human version in pills. Ivermectina gotas the human in drops bottles of 6 ml. The other option is Ivomec, injectable ( for cows)  but people in the rural areas of my country swallow it in small doses for the malaria.  I learn in the US this is considered a illegal idea so, just for information purposes as where it is taken and how much.
(Due to I have to buy everything out of pocket and help myself with God's help, I looked for more alternatives and asked my Dr about the veterinary versions of Ivermectin.  -My husband's relatives told me that the people living in the endemic areas injected themselves with "Ivomec" the Ivermectin made for cattle; they used one cm for 50 KILOS of weight.  - Well, my Dr said this medicine is as good as the human one and could be taken orally too.  He said he preferred the oral method to be able to control the dose according to the weight, and better absorption of it. I found the Ivomec very cheap in the internet but I think I don't have four stomachs as the cows do, so I looked into horse medicine because we all know these animals are the most expensive and the medicine for them is the very best.  I found many versions of horse Ivermectin for just $4.99 and it called my attention one product called "Zimectrin Gold" because it contains Ivermectin and also "Praziquantel" another anthelmintic used for bigger bugs including treating for flukes which I suspect I have and many Lymies have found to have too.  I bought it for $13.99 a tube with higher concentration and with the amount for a horse of 1,250 pounds, meaning I found medicine for long term treatment at a price I could certainly afford.  I called my Doc again and he told me to reduce the dose to the half of the horse dosing.  So I take max the amount marked for 100 pounds if I weigh 200.  One thing you must know, this medicine is the bitterest nasty of the planet.  I put the little amount of paste in a spoon, and then I grab it with my finger and put it deep inside my throat and then swallow it with water and try to eat some peanut butter or anything to pass that taste.  But listen, my Dr told me to have Ivermectin with the stomach empty, not meaning fasting but for example before going to sleep, two hours after my last meal.  This I did once a week and after feeling so good I stopped all medicines for a month, then tried another one called Triventor because this one has "Triclabendazole" to treat the flukes and just took two doses in two days and have not had any treatment since this two months ago and I pray thanking God every day I feel better and recovering!  Is this the cure?  I don't know, cannot tell yet; plus my heart and my body are still very battered after six years of antibiotics and extreme illness so I still won't sing victory, but yes I am feeling well.)
I share my experience and all my thoughts in my blog hoping to bring some light to others - many- who could be as desperate as I was after being so sick and the sicker I was the more Drs dismissed me.  I'm not saying take this medicines nor do as I did, just research and find out that Lyme Disease is also a parasitic infection and we will continue to be sick if Drs don't treat the parasites that came with the tick bite, I don't mean only the regular intestinal parasites but parasites in our blood inside our red blood cells, inside the white blood cells and inside our tissues, organs and everywhere!  
Denying the parasitic infection that comes from a vector borne infection is the most cruel ignorance of the medical field in the US.
I pray for Dr J in Maryland who diagnosed me and for my Dr JQP who takes my phone calls.  I have no words to thank my family for sending me so many medicines and to all who help me here; but my reason of doing all I do is to help my Lymie friends because there has to be light out of this tunnel and it looks like I found a piece of this puzzle I need to share, for free with no commercial obligations nor compromises.  Yes take antibiotics as needed but to recover from Lyme Disease and Babesia you do need anthelmintics. My thinking.  
May God guide me to say and do what is correct every day amen. May God guide you to do what you need to do to recover and heal.  I pray for your recovery and hope to share this light with love and happiness, wooo hooo, to recovery we go!

Hugs and big hugs to my friend E!!!!!!!!!!!!!



Would like to add a link to a great information my friend CH just sent me, it is a study made in Japan that shows that patients who received this medicine taken from the green tea "significantly (P<0.05) inhibited the growth of B. microti at doses of 5 and 10 mg/kg body weight, and the parasites completely cleared on day 14 and 16 post-inoculation in the 5 and 10 mg/kg treated groups, respectively. These findings highlight the potentiality of (-)-Epigallocatechin-3-gallate as a chemotherapeutic drug for the treatment of babesiosis.
PMID: 20025823 [PubMed - indexed for MEDLINE]" 
Thank you all for sharing all these with me!!!





Mi amiga periodista me pregunta como sobrevivo a la enfermedad de la garrapata y si tiene cura?
(Nota: vivo en Florida y se supone que aqui no decimos "bicho" porque los puertorriqueños se ofenden pues  lo consideran una mala palabra que significa el organo masculino? pero para nosotros solo quiere decir animal pequeño o hasta microorganismo, asi es que perdonenme el uso de esa palabra en este mensaje).

Entonces LYME DISEASE - La Enfermedad de la Garrapata tiene o no cura?  Esta es mi historia y mi opinion:

Mi caso es severo como el de muchos aqui y este pais lo niega pues no quieren que se sepa que tienen una enfermedad tipo malaria - peor; si compararamos el parasito de la malaria se mete entre el globulo rojo para vivir alli, luego va al higado y luego al cerebro y termina matando a su huesped.  En la enfermedad gringa la picadura es de un garrapatica muy pequeña que no solo transmite una bacteria sino varios tipos de bichos entre bacterias y parasitos y aun no se sabe cuales son todos, solo se le ha dado nombre a algunos y curiosamente no matan al huesped sino solo luego de muchos años largos de sufrimiento... - hay quienes dicen que la garrapatita fue creada como parte de la guerra biologica y se les escapo de su centro de investigaciones de Plum Island?  En todo caso por comparar solo uno de ellos, la Babesia es una infeccion donde son tres parasitos los que al mismo tiempo se meten entre el globulo rojo a comer y vivir!!  Osea es una triple malaria!!!!    Y por su parte la bacteria Borrelia, la base conocida de la infeccion, salta a los globulos blancos, daña el sistema immunologico y viaja entre los globulos blancos por todo el cuerpo para vivir a sus anchas...

De la sangre la infeccion viaja a a la base del cerebro y se mueve por entre el sistema linfatico, - son  todas las glandulas infectadas - uno de los primeros sintomas es el cuello inflamado, dolor en la base del craneo y tiroides; y desde alli se mueve por las venas al resto del cuerpo y desde las glandulas al cerebro, corazon y demas organos.. los sintomas son entonces perdida de memoria, vision borrosa, sintomas neurologicos como incremento o perdida del olfato y el gusto, incremento en la audicion - supe de una mujer quien sufrio tanto por lo del sonido que llego a suicidarse porque los medicos no le ayudaron durante años hasta que enloquecio.. tambien por la infeccion en el cerebro puede haber depresion clinica o unas iras como la demencia en los casos de sifilis o malaria cerebral... siguen luego sintomas como palpitaciones y arritmias, diarreas agudas, dolores artriticos, los musculos se caen, incremento subito o perdida subita de peso, dolores agudos de cabeza, de piernas, todos los nervios infectados dan unos calambres muy fuertes,  o en el riñon o de estomago; estamos hablando artritis y dolores musculares  - aqui les dan opiaceas para el dolor, conozco a una mujer que la tratan con 113 medicinas diarias, entre ellas cuatro opiaceas y morfina.. no, ella no es la mas enferma pero si una adicta... conozco otros casos de personas en cama sin levantarse 4 o 5 años... una joven de 24 años quien no logra permanencer sentada mas de 5 o 10 minutos porque se desmaya, despues de cientos de medicos - su familia tiene los recursos - un medico Ingles le encontro parasitos alojados en el sinus, la garganta y el cerebro...?  El tratamiento aqui es antibiotico intravenoso a razon de $2,500 por semana o por mes si tiene seguro?  osea es el negocio redondo! 
El medico que descubrio que la garrapata transmitia una bacteria, Dr Willy Burgdorfer,  tambien dijo que habian parasitos tipo filariales como los de la elefantiasis en Africa, o tambien llamada “Ceguera del Rio” o "Onchoneriasis"; pero aqui eso lo cubrieron con tierrita porque entonces estariamos hablando de una enfermedad peor que la malaria y la “Onchoneriasis” ?? eso seria la peor imagen en el mundo.  Solo por contarles me toco ver a una amiga con Lyme cuando le salio un bicho por el ojo, pequeñito, y luego empezamos a tomarles fotos y ya tengo un album… quiero decir, es una enfermedad de pelicula de terror que USA esconde!
Mi historia empieza desde el 2006. Pase por diez medicos y todos se pasaban la pelota caliente - aqui en la Florida no hay ni puede haber Lyme Disease, imposible!  Es una enfermedad que en su ciclo envuelve el paso por la rata y el venado - osea... seria como decir que Mickey y Bambi son transmisiores de una enfermedad casi mortal.. o que aqui no la saben curar? .... pero mi historia es comun, la mayoria de los enfermos con Lyme no solo sufren la terrible enfermedad sino el rechazo y la negacion de la mayoria de los medicos; creo que a los Doctores les da miedo enfrentar a un paciente multisintomatico, multiinfectado, o prefieren usar una evasiva y es mas facil decir que tiene menopausia o alergias? ... me costo $650 dolares el examen que decia que NO era menopausia... ombe si me dolio el bolsillo y el ego... entonces gracias al internet encontre el nombre de la enfermedad que tenia, Lyme Disease, y  luego fui a ver especialistas de enfermedades infeccionsas quienes igual lo negaron, "que si tenia alguna infeccion la habia traido de Colombia"? 
y entonces mi Primo me mando antibioticos desde Medellin para ayudarme, pero apenas los paraba me empeoraba;  luego gracias a Dios llame a mi medico de la epoca cuando vivimos en Cali - lo llame porque era un medico que iba a la casa a ver a sus pacientes muy sabio, muy estudioso y muy compasivo - y claro Dr J Q sabia mas de infecciones bacteriales y parasitarias que los medicos de aqui y me empezo a tratar por telefono primero la tiroides, me dio otros antibioticos pero cuando se me acababan yo empeoraba hasta no poderme mover para ir al baño…  luego de muchos meses sin mejorar al Doctor se le ocurrio intentar tratamiento antiparasitario? Aqui las entidades medicas especializadas decian que ni el Bactrim ni el Flagyl servian para tratar esta enfermedad.  Yo empece con Metronidazol y no solo senti mejoria sino que  por primera vez note algo de recuperacion, pero la infeccion aun era brutal.. entonces en el 2009 fui a ver a un medico en Maryland, ya fui capaz de viajar!  Este Doctor con solo verme reconocio varios sintomas como el "Bells Palsy" que es paralisis de un lado de la cara como si hubiera tenido un derrame, y miro mi cuello y la dificultad para tragar y el corazon, etc... me mando examenes de sangre para confirmar su diagnostico clinico: Lyme Disease!   y me dio antibioticos! ... Le rogue me hicieran un examen para ver si tenia parasitos intestinales pero no.. el Dr no trata parasitos... pero si llevo tres años con daño de estomago please...  los examenes mostraron que tenia la famosa bacteria Borrelia, tambien el parasito Babesia y que en mi sangre habian otros dos parasitos que no lograron saber que eran?  uno redondo muy numeroso tipo toxoplasmosis y otro alargado con bolitas en las puntas? ...  osea, para empezar 4 tipos de bichos sin examenes exhaustivos solo los basicos?

Mas me hubiera valido "coger" una malaria cuando me fui a vivir a la selva de Bahia Solano que esta infeccion gringa...

No tenia dinero para regresar a Maryland y el Dr no me iba a tratar por telefono; las inyecciones de penicilina me costaron $1,200 dls, cada 20 pastillas me valian $300 y era una lista interminable de gastos, sin decirles que los medicos especializados cobran $875 por la consulta y si es alguna preguntita telefonica cobran $10 por minuto? .. gracias a Dios mi familia me mando medicinas y aun cada vez que alguien viaja me traen medicinas y con eso me salvaron la vida - Dios les pague!  ... pero que conste que no me estoy quejando ni mas faltaba, solo era para que vieran como es la atencion medica en USA; antes a mi me ha ido super bien porque las personas que conozco con LD se gastan entre 40 y 60 mil dolares en su tratamiento anual y aun siguen muy enfermos o recaen constantemente.. yo no me quejo, por el contrario mi familia me ha enviado tantas medicinas de Colombia que tengo un arsenal repleto;  pero la gran diferencia ha sido ese medico Caleño quien me dio Ivermectina... siii, la medicina que empezo como Ivomec para purgar el ganado?  muuu, me salvo la vida!!!!  No, no es un comercial!!!  Si no hay tratamiento antiparasitario no hay recuperacion en el Lyme Disease, digo yo!
El Dr me mando dosis semanales muy bajitas, combinadas con antibioticos y ahora al escondido de el me tome una medicina para caballos (Zimectrin que ademas tiene prazicuantel) - creo que es la mejor medicina que existe.. no, no me creo llegua, apenas si soy una mula con aspiraciones!!!!!!  Y me he mejorado muchisimo, estoy muy funcional digamos.. con sintomas de corazon y otros porque ademas tantos años de antibioticos al que no matan lo desbaratan como el matrimonio... pero ahi voy bien la mayoria de las veces. 

Y tengo un blog y como 600 amigos de Facebook con la misma enfermedad y les cuento sobre la Ivermectina y hay varios a quienes les he dado mi medicina y todos han mostrado recuperacion - una sra luego de 4 años en cama ya me escribio que fue a comprarle regalo al nieto y fue a mercar el otro dia y tambien fue a visitar a su hermana...

Entonces, respondo, no se si el Lyme Disease se cura o no...  no lo se.   En este momento aqui hay cientos de tratamientos muy costosos, inclusive han hecho los llamados "protocolos patentados" para tratar el Lyme pero nadie habla de curarlo solo de "remision"; muchos hacen tratamientos con medicinas herbales o  maquinas que curan y miles de expertos opinan diariamente...  y obvio que hay una gigantezca problematica politica y social detras de esta enfermedad, como la sifilis o el sida, pero esta no la quieren enfrentar o la quieren usar para enriquecer las farmaceuticas porque afecta a personas de todas las edades, no discrimina en sexo ni raza; causa cientos de sintomas que hacen las riqueza de muchos especialistas y es la enfermedad de siglo porque ya se rego por Europa y Africa... no se si esta en Sur America?  

Tal vez encuentren la cura una vez se convierta en pandemia y vendan su formula magica?  O tal vez el Lyme Disease acabe con la humanidad? Suena como a una enfermedad de Nostradamus "pediran la muerte a gritos"?   y tambien algunos dicen que este es el GU chino que mato a miles ... no se, la bolita de cristal no me funciona bien ultimamente  para saber que va a pasar, se me daño el olfato perdiodistico con tanta infeccion y subjetividad? 
... yo solo se que el presente es lo unico que tenemos y que todo bien!

Antes vivi en una velocidad ultrasonido, cinco minutos para escribir una nota antes que saliera al aire, ahora conoci el lado de los lentos que estorban en la fila... cerrando mi circulo!
Hasta hoy en medio de todo, he aprendido mucho y Soy feliz!!!

Abrazos... no me imagine contar mi historia pero quiza le sirva a alguien... ojala!

Maria J.



This is not good news but very needed to open the eyes and properly treat this Lyme, because Borrelia enters the immune system some big bad opportunistic bugs show up and if not treated well, there is no recovery at all... many Lymies have shown to have FLUKES OR PARAGONIMUS... sometimes Praziquantel could help (I found it in Zimectrin Gold for horses and there is a human version in the US); but unfortunately the only medicine that really seems to work for treating flukes is  called TRICLABENDAZOLE, but the human version Fasinex is almost impossible to find anywhere in the world,  so most countries have to treat with the veterinary version.  If the person has flukes or paragonimus could get cancer if not properly treated and even after being treated; most lung problems are from the flukes, most liver problems are from these too and they also could cause intestinal parasitic infection.  Please note these super mega bugs are not being treated with the antibiotics you have been taking, nor the IV abx, nor oral and less herbals; if the person has flukes the medicine has to be as strong and equivalent as the bug.  
This is not bacteria, nor filarial parasites, nor the common spaghetti worms some might have seen in their toilets, these are the masters of disguise, real huge monster demons!  
 The way to test is in stool samples if the lab is looking for them, or if you see your "samples" like if you had eaten black beans... or with some brown seeds like whole almonds... plus the symptoms: Symptoms of parasite infection, specifically fascioliasis "include headaches, rashes, muscle pain, jaundice, abdominal pain, loss of appetite, anemia, nausea, and vomiting".  - And there might be other testing like DNA art testing or the biofeedback machines?  those might save our lives I think if we get a proper dgx.
This is other reading that states that the other anthelmintics could work but it is an older article, I present it here just for information: "Symptoms of schistosomiasis appear in three distinct phases.  In the initial phase, symptoms include:  fever, skin rash, abdominal pain, bronchitis, enlargement of the liver and spleen, and diarrhea.  In the intermediate phase, symptoms include pathological changes in the intestinal and urinary tracts, and eggs in the urine and feces.  The final phase results in complications involving major bodily systems."
"Diagnosis is accomplished by finding eggs in the urine or feces. The most effective drugs for treating schistosomoiasis are organic trivalent antimonials.  However, these drugs are toxic to humans, and of these drugs, only pentavalent stibogluconate is still in use.
The current drug of choice is praziquantel.  Other drugs used to treat schistosomiasis include metrifonate, oxamniquine, bithionol, albendazole, or mebendazole.  The mechanism of these modern drugs is not known.  However, it is known that one of the drugs (albendazole) starves the parasite and its offspring."... NOT TRUE, TRICLABENDAZOLE IS THE CHOICE NOW!
If I may add, I found a veterinary medicine called TRIVENTOR that contains all the anthelmintics such as Triclabendazole, febendazole, Ivermectina and Praziquantel - does not contain Albendazole but I guess it is because the Albenda is the one that most probably hurt the Central Nervous system, but opposite of what we think, Albenda is one of the antiparasitics preffered by the American Doctors because they do not know the other anthelmintics plus they ignore the studies about the central nervous system...
Anyways, I'm talking about monsters, huge, affecting Lyme patients who's bodies and immune system cannot combat by itself!  Hope we all could get tested and treated against FLUKES!.
Read this: 
"Symptoms of schistosomiasis are caused by the body's reaction to the eggs produced by worms, not by the worms themselves.
Digestive symptoms: The following list incomplete:
abdominal pain, nausea, vomiting, inability to pass gas, abdominal pain on breathing, constipation, diarrhea, abdominal sensitivity, abdominal pain near navel, abdominal pain on sneezing, abdominal pain on activity, right-side abdominal pain, abdominal pain on coughing, abdominal swelling, upper abdominal discomfort, abdominal burning, abdominal bloating, malabsorption, partial intestinal blockage, Diverticulosis* Acute kidney failure ... nausea, vomiting, diarrhea * Bowel Obstruction ... green vomit, constipation, fecal vomiting, vomiting, abdominal swelling http://www.earthtym.net/ref-fluke-info.htm"

The study made in Egipt that showed Triclabendazole as the proper medicine to treat for flukes here: 
Links of pictures of parasites a wonderful blog, by
Carol Poore, thank you:

And more Links and info about triclabendazole,

"[Fascioliasis (treatment)]1Triclabendazole is used as a primary agent in the treatment of fascioliasis caused by Fasciola hepatica (sheep liver fluke) and Fasciola gigantica (giant liver fluke). {01} {02} {07} {08} {11} {13}

[Paragonimiasis (treatment)]1—Triclabendazole is used as an alternative agent in the treatment of paragonimiasis caused by Paragonimus westermani (lung fluke) {01}"

Mechanism of action/Effect:

Fasciolicidal not only against the adult worms present in the biliary ducts, but also against the immature larval stages of Fasciola migrating through the hepatic parenchyma; the mechanism of action is not thoroughly understood; however, triclabendazole is shown to penetrate into liver flukes by transtegumentary absorption followed by inhibition of the parasite's motility, probably related to the destruction of the microtubular structure, resulting in the death of the parasite; the immobilizing effect is paralleled by changes in the parasite's resting tegumental membrane potential, strongly inhibiting the release of proteolytic enzymes, a process that appears critical to the survival of the parasite {05} {06} {07}.

Following oral administration, triclabendazole is absorbed from the gastrointestinal tract; absorption is increased twofold to threefold when triclabendazole is taken after a fatty meal {02} {08}. Distribution:
Triclabendazole and its metabolites attain high concentrations in the biliary tract, through which they are excreted back into the intestine over a period of several days {02}; less than 1% of orally administered triclabendazole is distributed into breast milk {09}. Biotransformation:
Triclabendazole is oxidized to sulfoxide (the primary metabolite) and sulfone (present in lesser amounts) over the first 24 hours following oral administration {02}.

 Time to peak concentration:
Approximately 8 hours {02}.

    Fecal—Approximately 95% of orally administered triclabendazole (unchanged or as the primary metabolite) is excreted in the feces {09}.      Renal—Approximately 2% is excreted in the urine {09}. Precautions to Consider
Mutagenicity Studies conducted in laboratory animals have not shown triclabendazole to be mutagenic {07} {08}"

Only vet med and it is considered illegal in the US? ... :(